Nanomaterials
The Johns Hopkins Center for Translational Immunoengineering research team is bioengineering nanoimmunomaterial tools (NIMs) with new biomaterials and particles for immunomodulation. These particle-based biotechnologies function through intracellular delivery of nucleic acids, extracellular presentation of biological molecules from biomimetic surfaces, or both. By controlling NIMS physical, chemical, and biological properties, researchers can engineer T cells, dendritic cells, macrophages, and cells in other microenvironments. In many cases, NIMs can target cell-specific delivery. With the aid of NIMs, the efficacy of adoptive cell transfer (ACT) and particle-based acellular immunotherapeutics can be improved in multiple fields and human health applications.
Key properties of PBAEs and their development
Poly(beta-amino ester)s as Gene Delivery Vehicles: Challenges and Opportunities
Synthetic, biodegradable nanoparticles that can genetically reprogram cancer cells and their microenvironment in situ
In situ Genetic Engineering of Tumors for Long-Lasting and Systemic Immunotherapy
A new type of biomimetic particle to induce tolerance
Biomimetic Tolerogenic Artificial Antigen Presenting Cells for Regulatory T Cell Induction
PLGA/PBAE aAPCs as a biocompatible, directly injectable acellular therapy for cancer immunotherapy
Biodegradable Cationic Polymer Blends for Fabrication of Enhanced Artificial Antigen Presenting Cells to Treat Melanoma
Efficient mRNA delivery nanoparticles
High-Throughput Bioassay Enables Tuning of Polyester Nanoparticles for Cellular Uptake, Endosomal Escape, and Systemic Delivery of mRNA
Barcoded nanoparticles
High-Throughput Evaluation of Polymeric Nanoparticles for Tissue-Targeted Gene Expression Using Barcoded Plasmid DNA
siRNA delivery nanoparticles
Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy
Gene editing nanoparticles
Poly(Beta-Amino Ester) Nanoparticles Enable Nonviral Delivery of CRISPR-Cas9 Plasmids for Gene Knockout and Gene Deletion
Biomimetic nanoparticles to remove toxins
Biomimetic Anisotropic Polymeric Nanoparticles Coated with Red Blood Cell Membranes for Enhanced Circulation and Toxin Removal
Nanoparticles for cytosolic protein delivery
Carboxylated Branched Poly(beta-amino ester) Nanoparticles Enable Robust Cytosolic Protein Delivery and CRISPR/Cas9 Gene Editing
Nanoparticles to cross the blood brain barrier
Engineered Nanoparticles for Systemic siRNA Delivery to Malignant Brain Tumors
Theranostic nanoparticles
Polymeric Nanoparticles for Dual-Targeted Theranostic Gene Delivery to Hepatocellular Carcinoma