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Immunoengineering research by Johns Hopkins biomedical engineers and JH-TIE researcher was recently featured on the cover of the journal JCI Insight. The article, “Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity,” was selected and featured as the cover for the September 2024 issue. The cover art was illustrated by Ann Seliger, a recent […]

Si-Sam Kang, fourth year PhD student receives PhRMA Foundation Predoctoral Fellowship in drug delivery to improve adoptive cell therapy. Read the full story by PhRMA.

Story by Catherine Graham and posted on the Hub. Benjamin Biggs, Engr ’23, a second-year doctoral student in biomedical engineering at Johns Hopkins University, is among 50 exceptional STEM scholars selected to receive a 2024 Quad Fellowship. The Quad Fellowship provides awardees from Australia, India, Japan, the U.S., and some Southeast Asian countries with $40,000 in […]

Story by Kate Olsen and the National Institute of Biomedical Imaging and Bioengineering Targeted, biodegradable nanoparticles used in preclinical cancer treatment regimen Vaccines work by giving our immune system a ‘heads up’ about a known threat. They are traditionally given before we encounter a pathogen (such as the influenza virus), allowing our bodies to mount a better […]

Story by Johns Hopkins Medicine. Johns Hopkins Medicine researchers have developed a color-coded test that quickly signals whether newly developed nanoparticles — ultra small compartments designed to ferry medicines, vaccines and other therapies — deliver their cargo into target cells. Historically, nanoparticles have a very low delivery rate to the cytosol, the inside compartment of [...]

JH-TIE center director Jonathan Schneck discusses his group’s work on the development of a high-throughput system to analyze neoepitope-specific T-cell immune responses.

In a paper published in the September issue of Nano Letters, Hickey, et al. reported a series of technologies that streamline enrichment, expansion, and detection of a wide range of antigen-specific T cells for cancer, infectious disease, and autoimmunity. The authors developed a concept of “adaptive artificial antigen presenting cells,” which can target an array of T [...]

Story by Johns Hopkins Medicine Red blood cells not only carry oxygen from one part of the body to another, they also act as sponges in the circulatory system, soaking up toxins such as poisons shed from infections. The more red blood cells available in the blood system, the faster the recovery from toxin-related threats [...]

Story by Johns Hopkins Medicine Scientists at Johns Hopkins report they have designed and successfully tested an experimental, super small package able to deliver molecular signals that tag implanted human cancer cells in mice and make them visible for destruction by the animals' immune systems. The new method was developed, say the researchers, to deliver [...]

Story by Johns Hopkins Medicine Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a “suicide gene” to pediatric brain tumor cells implanted in the brains of mice. The poly(beta-amino ester) nanoparticles, known as PBAEs, were part of a treatment that also used a drug to kill the cells and [...]

Story by Johns Hopkins Medicine. Scientists at Johns Hopkins Medicine report they have created a tiny, nanosize container that can slip inside cells and deliver protein-based medicines and gene therapies of any size — even hefty ones attached to the gene-editing tool called CRISPR. If their creation – constructed of a biodegradable polymer — passes [...]

This press release is by Johns Hopkins Medicine and appeared in the Newsroom on November 13, 2019.  If the saying that two heads are better than one is true, then joining two fields of science may be better than one to spur more advances in medicine. With a $6.7 million, five-year grant from the National Institutes of [...]