Artificial Antigen Presenting Cells (aAPC)

Development and Use

Design considerations and progress made in the development of ex vivo and in vivo technologies for activating antigen-specific T cells.

Biomaterials to Enhance Antigen-Specific T Cell Expansion for Cancer Immunotherapy

Enrichment + Expansion strategy to rapidly expand tumor-specific T cells from rare naïve precursors and predicted neo-epitope responses.

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy

Platforms to process and detect CD8+ T cells specific for rare cancer neoantigens, commensal bacterial cross-reactive epitopes, and human viral and melanoma antigens.

Adaptive Nanoparticle Platforms for High Throughput Expansion and Detection of Antigen-Specific T Cells

Biodegradable ellipsoidal naAPCs that mimic the T-Cell/APC interaction better than equivalent spherical naAPCs.

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-cell Activation

Combination of aAPCs with anti-CD28 costimulatory and human MHC class I molecules loaded with antigenic peptides to rapidly expand tumor antigen-specific T cells.

Rapid Expansion of Highly Functional Antigen-Specific T Cells from Patients with Melanoma by Nanoscale Artificial Antigen-Presenting Cells

Video Articles

Code

ImmunoMap

Despite a dramatic increase in T-cell receptor (TCR) sequencing, few approaches biologically parse the data in a fashion that both helps yield new information about immune responses and may guide immunotherapeutic interventions. To address this issue, we developed a method, ImmunoMap, that utilizes a sequence analysis approach inspired by phylogenetics to examine TCR repertoire relatedness.

Non-aAPC Methods for Modulating T Cell Response

A hyaluronic acid-based hydrogel for T-cell activation.

Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy

A nanoparticle platform that overcomes the immunosuppressive tumor microenvironment.

Dual Targeting Nanoparticle Stimulates the Immune System To Inhibit Tumor Growth

An approach to selectively bind antigen-specific cytotoxic T cells and redirect them to kill tumors.

Antigen-Specific T Cell Redirectors: A Nanoparticle Based Approach for Redirecting T Cells

Advantages and shortcomings of a non-cell-based ‘killer artificial antigen-presenting cell’ strategy to overcome cell-based treatments of T-cell-mediated autoimmunity.

Killer Artificial Antigen-Presenting Cells: The Synthetic Embodiment of a ‘Guided Missile’