A bioinformatics tool for T-cell repertoire analysis.


Despite a dramatic increase in T-cell receptor (TCR) sequencing, few approaches biologically parse the data in a fashion that both helps yield new information about immune responses and may guide immunotherapeutic interventions. To address this issue, ImmunoMap was developed to use a sequence analysis approach inspired by phylogenetics to examine TCR repertoire relatedness.

TCR analysis for COVID-19 and influenza A M1 epitope.

COVID-19 and Influenza A Cross Reference

Epidemiological studies early in the pandemic showed a geographical association between high influenza vaccination rates and lower incidence of SARS-CoV-2 infection. Therefore, analysis was performed on whether exposure to influenza A virus antigens could influence the T cell repertoire in response to SARS-CoV-2. Code was created, and available on GitHub, to analize and cross reference results.