Projects Categories: Collaborative Projects

Collaborative Project #10: Toward Safer Gene Therapy for Hemophilia A

07/30/2024

Collaborating Investigator: Roland Herzog, PhD Affiliation: Riley Children’s Foundation Professor of Immunology, Indiana University   Funding Source: NIH Funding: Number: P01HL160472  Project Period: 02/05/22-01/31/27   Significance The X-linked bleeding disorder Hemophilia A is caused by a deficiency in the clotting protein factor VIII (FVIII), and FVIII gene therapy thus provides a promising strategy for disease treatment....

Collaborative Project #9: Novel Macrophage and Regulatory T Cell Interactions that Promote the Pathogenesis of Duchenne Muscular Dystrophy    

07/30/2024

Collaborating Investigator: Armando Villalta, PhD Affiliation: Assistant Professor, Physiology & Biophysics; University of California, Irvine Funding Source: NIHGrant Number: 2R01NS120060  Project Period: 09/30/20-08/31/25 Significance Duchenne muscular dystrophy (DMD) is caused by loss-of-function mutations in the dystrophin gene that lead to widespread muscle degeneration, and the disease is therefore frequently treated via dystrophin...

Collaborative Project #8: Novel Strategies for Immunological Reprogramming 

07/30/2024

Collaborating Investigator: Dino Di Carlo, PhD Affiliation: Cleveland ClinicDirector, Lerner Research Institute, Cleveland Clinic  Funding Source: NSFGrant Number: 2149551   Project Period: 09/15/22-08/31/25 Significance The Di Carlo Lab leverages microfluidics, microfabrication, and nanotechnologies to develop interfaces with cells and molecules for applications in disease diagnosis, therapeutic discovery, tissue regeneration, and...