Advances in Immunoengineering: Fundamentals and Cutting Edge Advances (2022)

The immunoengineering field is transforming cancer, autoimmunity, regeneration, and transplantation treatments by combining the diverse and complex fields of engineering and immunology. There is a significant need to train engineers in immunology and immunologists in quantitative engineering techniques. Moreover, there is a need to bridge basic immunological discoveries with advances in clinical application. This virtual workshop will review immune system fundamentals and components, engineering strategies to modulate the immune system, and clinical applications.

After attending this workshop, the learner will demonstrate the ability to:
– Review the fundamentals and recent discoveries in the function of the immune system.
– Identify engineering strategies to manipulate the immune system.
– Describe the clinical applications of immunoengineering.

Target Audience
The workshop is designed for graduate students, medical students, residents, and fellows in engineering, immunology, and related fields. Engineering and clinical faculty, and industry members will benefit from the course as well.

Dates and Time
Every Tuesday and Thursday, January 4 – 27, 2022, from 4:00 pm – 5:30 pm ET.

You only need to register once to attend all dates. Registration is allowed at any time.

This workshop is eligible for CME credit and offered as a two-credit course for Johns Hopkins students. The course is listed as EN.580.543 (for undergraduate students) and EN.580.843 (for graduate students) Independent Study: Advances in Immunoengineering in SIS. Students need to register for the course and the workshop.


Week 1 – T-Cell Engineering and Immunometabolism

Tuesday, January 4, 2022 Thursday, January 6, 2022
Cassian Yee

T Cell Therapy of Cancer: the New Math

Pedro Romero

Modulating Antigen-specific CD8 T Cell Differentiation for Immunotherapy of Cancer

Kellie N. Smith

Integrated Multi-Omics for Tumor-Reactive T Cell Profiling

Erika Pearce

Mitochondrial Shape-Shifting in the CD4+ T Cell Response

Week 2 – Regenerative Immunology and T Cell Programming

Tuesday, January 11, 2022 Thursday, January 13, 2022
Stephen Badylak

Immunoengineering … Finally!

Greg Delgoffe

Metabolic Reprogramming to Improve T Cell Function

Jennifer Elisseeff

Immune Changes with Aging and Implications for Regenerative Medicine

Jonathan Schneck

Engineering Artificial Antigen Presenting Cells, aAPC, for Cancer Immunotherapy: From Bench to Bedside

Week 3 – Immunotherapy, Vaccine, and Autoimmunity

Tuesday, January 18, 2022 Thursday, January 20, 2022
Matthias Stephan

Creating Living Drugs with Synthetic Compounds

Robert Seder

Systemic Delivery of a Nanoparticle Neoantigen Cancer Vaccine Generates Effective Antitumor Immunity Through CD8+ T Cells and Innate Stimulation

Ankur Singh

Decoding Immunity Using Engineered Immune Organoids

Pere Santamaria

In Vivo Re-programming of Autoantigen-experienced T-follicular Helper Cells for the Treatment of Autoimmunity

Week 4 – Immunoengineering, Tissue Context, and Immunotherapies

Tuesday, January 25, 2022 Thursday, January 27, 2022
David Mooney

Biomaterials for T Cell Immunity

Donna Farber

Localized Adaptation and Tissue Residence of Immune Cells

Megan Sykes

Tracking the Human Alloresponse in Transplant Recipients

John Wherry

Immunity to SARS-CoV-2 Vaccination